| Bioactivity | sEH inhibitor-8 (compound 15) is a sEH inhibitor with IC50 values of 0.4 and 1.0 nM for human sEH and murine sEH, respectively. sEH inhibitor-8 inhibits mechanical hypersensitivity in mouse models. sEH inhibitor-8 can be used for the research of inflammation[1]. |
| Invitro | sEH inhibitor-8 (0-1 μM) inhibits human sEH and murine sEH with IC50 values of 0.4 and 1.0 nM, respectively[1]. sEH inhibitor-8 (0-100 μM) shows inhibition to cytochrome with IC50 values of 34, 38 and 1 μM for CYP 2C9, CYP 2C19 and CYP 3A4, respectively[1]. Western Blot Analysis[1] Cell Line: |
| In Vivo | sEH inhibitor-8 (1.25-5 mg/kg; s.c. once) inhibits mechanical hypersensitivity in vivo[1]. 1.19Pharmacokinetic Properties of sEH inhibitor-8 in Mice [1]. |
| Name | sEH inhibitor-8 |
| Formula | C27H36ClN3O3 |
| Molar Mass | 486.05 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Codony S, et al. Synthesis, In Vitro Profiling, and In Vivo Evaluation of Benzohomoadamantane-Based Ureas for Visceral Pain: A New Indication for Soluble Epoxide Hydrolase Inhibitors. J Med Chem. 2022 Oct 27;65(20):13660-13680. |