| Bioactivity | sEH inhibitor-11 (compound 35) is a sEH inhibitor with an IC50 value of 0.3 μM. sEH inhibitor-11 can be used for the research of inflammation[1]. |
| Target | IC50: 0.3 μM (sEH) |
| Invitro | sEH inhibitor-11 (0-10 μM; 10 min) inhibits sEH activity with an IC50 value of 0.3 μM[1].sEH inhibitor-11 (0-10 μM) inhibits 5-lipoxygenase-activating protein (FLAP)-mediated cellular leukotriene (LT) formation with an IC50 value of ＞10 μM[1].sEH inhibitor-11 (15 min) remains the activity of 5-lipoxygenase (5-LO) product formation in neutrophils with 93.5% and 62.1% at doses of 1 and 10 μM, respectively[1]. |
| Name | sEH inhibitor-11 |
| Formula | C21H22ClN3O2S |
| Molar Mass | 415.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Turanlı S, et al. Quinazoline-4(3H)-one-7-carboxamide Derivatives as Human Soluble Epoxide Hydrolase Inhibitors with Developable 5-Lipoxygenase Activating Protein Inhibition. ACS Omega. 2022 Oct 5;7(41):36354-36365. |
sEH inhibitor-11
CAS: F: C21H22ClN3O2S W: 415.94
sEH inhibitor-11 (compound 35) is a sEH inhibitor with an IC50 value of 0.3 μM. sEH inhibitor-11 can be used for the re
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This product is for research use only, not for human use. We do not sell to patients.