Bioactivity | rel-Zotatifin is the racemic isomer of Zotatifin, acts as an eIF4A inhibitor with activity less than Zotatifin. Zotatifin (eFT226) is a potent, selective, and well-tolerated eIF4A inhibitor. Zotatifin promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5’-UTRs (IC50=2 nM) and interferes with the assembly of the eIF4F initiation complex[1]. | ||||||||||||
Name | rel-Zotatifin | ||||||||||||
CAS | 2098191-54-7 | ||||||||||||
Formula | C28H29N3O5 | ||||||||||||
Molar Mass | 487.55 | ||||||||||||
Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
Storage |
|