| Bioactivity | rac-BHFF is a potent and orally active allosteric enhancer of GABAB receptor[1]. |
| In Vivo | rac-BHFF has anxiolytic-like properties in stress-induced hyperthermia (SIH) in mice[1].rac-BHFF (3, 10, 30 and 100 mg/kg, p.o.) reverses SIH and high significance was reached for 100 mg kg−1 (P<0.001)[1]. Animal Model: |
| Name | rac-BHFF |
| CAS | 123557-91-5 |
| Formula | C17H21F3O3 |
| Molar Mass | 330.34 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. P Malherbe, et al. Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br J Pharmacol. 2008 Jun;154(4):797-811. |