| Bioactivity | proMMP-9 inhibitor-3c (compound 3c) is a potent proMMP-9 inhibitor. proMMP-9 inhibitor-3c is specific for binding to the proMMP-9 hemopexin-like domain (Kd=320 nM). proMMP-9 inhibitor-3c disruption of MMP-9 homodimerization prevents association of proMMP-9 with both α4β1 integrin and CD44 and results in the dissociation of EGFR. This disruption results in decreased phosphorylation of Src and its downstream target proteins focal adhesion kinase (FAK) and paxillin (PAX)[1]. |
| Invitro | proMMP-9 inhibitor-3c (compound 3c) (500 nM)可阻止癌细胞对基底膜的侵袭，减少血管生成[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> proMMP-9 inhibitor-3c 相关抗体: |
| CAS | 2138321-18-1 |
| Formula | C18H20FN3O2S |
| Molar Mass | 361.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alford VM, et al. Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions. ACS Chem Biol. 2017 Nov 17;12(11):2788-2803. |
proMMP-9 inhibitor-3c
CAS: 2138321-18-1 F: C18H20FN3O2S W: 361.43
proMMP-9 inhibitor-3c (compound 3c) is a potent proMMP-9 inhibitor. proMMP-9 inhibitor-3c is specific for binding to the
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