pan-KRAS-IN-16

CAS: 2368246-78-8 F: C24H26N2O3 W: 390.47

pan-KRAS-IN-16 is an anti-RAS small molecule derived from an intracellular antibody fragment with pan-RAS-effector prote

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Bioactivity	pan-KRAS-IN-16 is an anti-RAS small molecule derived from an intracellular antibody fragment with pan-RAS-effector protein-protein interaction inhibitor properties. pan-KRAS-IN-16 binds to a hydrophobic pocket near to the effector-binding switch regions of RAS. pan-KRAS-IN-16 prevents endogenous RAS-dependent signaling in tumor cell lines[1].
CAS	2368246-78-8
Formula	C24H26N2O3
Molar Mass	390.47
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Bery N, et al. BRET-based RAS biosensors that show a novel small molecule is an inhibitor of RAS-effector protein-protein interactions. Elife. 2018 Jul 10;7:e37122.