| Bioactivity | palm-PrRP31 is a potent dual receptor agonist for both GPR10 (with an EC50 of 72±6 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure[1]. |
| Sequence | {N-palm-Ser}-Arg-Thr-His-Arg-His-Ser-Met-Glu-Ile-Arg-Thr-Pro-Asp-Ile-Asn-Pro-Ala-Trp-Tyr-Ala-Ser-Arg-Gly-Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2 (palm=palmitoyl (C16)) |
| Shortening | {N-palm-Ser}-RTHRHSMEIRTPDINPAWYASRGIRPVGRF-NH2 (palm=palmitoyl (C16)) |
| Formula | C176H282N56O43S |
| Molar Mass | 3902.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Strnadová V, et al. Search for lipidized PrRP analogs with strong anorexigenic effect: in vitro and in vivo studies[J]. Neuropeptides, 2023, 98: 102319. |