p53-MDM2-IN-3_product_DataBase

Bioactivity	p53-MDM2-IN-3 (Compound 5s) is an orally active p53-MDM2 inhibitor with a Ki value of 0.25 μM. p53-MDM2-IN-3 exerts antitumor activity by inhibiting NF-κB pathway[1].
Invitro	p53-MDM2-IN-3 (0.1-20 μM, 4 h) 剂量依赖性增加 A549 细胞质和细胞核中 p65 水平[1]。p53-MDM2-IN-3 (0.1-10 μM, 4 h) 在 A549 细胞中选择性激活 p53 或抑制 NF-κB通路[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> p53-MDM2-IN-3 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	p53-MDM2-IN-3 (200 mg/kg, 灌胃, 14 天) 在 A549 异种移植模型中有效抑制肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1542066-74-9
Formula	C30H25BrFN5O
Molar Mass	570.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhuang C, et al. Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway. J Med Chem. 2014 Feb 13;57(3):567-77.

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