| Bioactivity | p53 Activator 14 (Compound 7A) is a derivative of Neratinib (HY-32721), that induces DNA damage, activates p53, and inhibits the proliferation of multi cancer cells (IC50=7.21 μM for HCT116 cell). p53 Activator 14 inhibits the adhesion, migration and invasion of HCT116, arrests the cell cycle, and induces apoptosis. p53 Activator 14 inhibits angiogenesis and exhibits antitumor efficacy in chick chorioallantoic membrane (CAM) model[1]. |
| CAS | 2922588-44-9 |
| Formula | C28H29ClN4O3 |
| Molar Mass | 505.01 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu ZY, et al., Neratinib derivative 7A induces apoptosis in colon cancer cells via the p53 pathway. Bioorg Med Chem Lett. 2025 Mar 1;117:130069. |
p53 Activator 14
CAS: 2922588-44-9 F: C28H29ClN4O3 W: 505.01
p53 Activator 14 (Compound 7A) is a derivative of Neratinib (HY-32721), that induces DNA damage, activates p53, and inhi
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