| Bioactivity | p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. |
| Target | Ki: 32.6 μM (TPH) |
| Invitro | p-Ethynylphenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin[1].p-Ethynylphenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors (5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6, and 5-HT7)[1]. |
| In Vivo | p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase[1]. Animal Model: |
| Name | p-Ethynylphenylalanine hydrochloride |
| CAS | 188640-63-3 |
| Formula | C11H12ClNO2 |
| Molar Mass | 225.67 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
| Reference | [1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73. |
p-Ethynylphenylalanine hydrochloride
CAS: 188640-63-3 F: C11H12ClNO2 W: 225.67
p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and co
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