| Bioactivity | o-3M3FBS is the negative control of m-3M3FBS. o-3M3FBS inhibits inward and outward currents via mechanisms independent of PLC acting in an antagonistic manner. In contrast, o-3M3FBS also causes an increase in [Ca2+]i in an agonistic manner[1]. |
| In Vivo | o-3M3FBS (10 μM) decreases AUC from 1058±189 g/min in control (in the presence of TTX) to 840±134 g/min. Higher concentration of o-3M3FBS (25 μM) further decreases AUC to 457±59 g/min[1]. |
| Name | o-3M3FBS |
| CAS | 313981-55-4 |
| Formula | C16H16F3NO2S |
| Molar Mass | 343.36 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Dwyer L, et al. Phospholipase C-independent effects of 3M3FBS in murine colon. Eur J Pharmacol. 2010;628(1-3):187-194. |
o-3M3FBS
CAS: 313981-55-4 F: C16H16F3NO2S W: 343.36
o-3M3FBS is the negative control of m-3M3FBS. o-3M3FBS inhibits inward and outward currents via mechanisms independent o
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