| Bioactivity | Nsp12-IN-1is a nucleoside analogue. Nsp12-IN-1 can block the synthesis of viral RNA and inhibit viral replication. Nsp12-IN-1 can be used in the study of pan-coronavirus[1]. |
| Invitro | Nsp12-IN-1 具有高选择性指数，在有效抗病毒浓度下对细胞的毒性较小，显示出对SARS-CoV-2的抗病毒活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> nsp12-IN-1 相关抗体: |
| In Vivo | Nsp12-IN-1 (2 mg/kg, i.v.; 30mg/kg p.o.; 24h) 口服生物利用度有所提高，但化合物的绝对生物利用度仍然较低[1]。药代动力学分析在雌性 Balb-c 小鼠[1]药代动力学分析[1]Dosed compound |
| Formula | C13H16FN5O5 |
| Molar Mass | 341.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mesaros E F, Dugan B J, Gao M, et al. Discovery of C-Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2[J]. ACS Infectious Diseases, 2024. |