| Bioactivity | malonyl-NAC increases cellular propylation, resulting in reduced endogenous GAPDH activity. malonyl-NAC increases GAPDH malonylation in cells and inhibits pyruvate kinase activity. In addition, malonyl-NAC limits the metabolism and proliferation of a highly glycolytic kidney cancer cell line harboring a tricarboxylic acid cycle mutation[1]. |
| Name | malonyl-NAC |
| CAS | 2361327-06-0 |
| Formula | C9H15NO4S |
| Molar Mass | 233.28 |
| Appearance | 油状物 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Kulkarni RA, et al. Discovering Targets of Non-enzymatic Acylation by Thioester Reactivity Profiling. Cell Chem Biol. 2017 Feb 16;24(2):231-242. |
malonyl-NAC
CAS: 2361327-06-0 F: C9H15NO4S W: 233.28
malonyl-NAC increases cellular propylation, resulting in reduced endogenous GAPDH activity. malonyl-NAC increases GAPDH
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