| Bioactivity | mSIRK (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 μM. mSIRK disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange[1]. |
| Name | mSIRK |
| CAS | 593267-11-9 |
| Sequence | {Myr}-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp |
| Shortening | {Myr}-SIRKALNILGYPDYD |
| Formula | C93H150N20O25 |
| Molar Mass | 1948.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Farida Goubaeva, et al. Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein βγ Subunit-binding Peptides. J Biol Chem. 2003 May 30;278(22):19634-41. |