| Bioactivity | mSIRK TFA (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 μM. mSIRK TFA disrupts the interaction between α and βγ subunits and promotes α subunit dissociation without stimulating nucleotide exchange[1]. | ||||||
| Sequence | {Myr}-Ser-Ile-Arg-Lys-Ala-Leu-Asn-Ile-Leu-Gly-Tyr-Pro-Asp-Tyr-Asp | ||||||
| Shortening | {Myr}-SIRKALNILGYPDYD | ||||||
| Formula | C93H150N20O25.xC2HF3O2 | ||||||
| Molar Mass | 1948.31 (free acid) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Farida Goubaeva, et al. Stimulation of Cellular Signaling and G Protein Subunit Dissociation by G Protein βγ Subunit-binding Peptides. J Biol Chem. 2003 May 30;278(22):19634-41. |
mSIRK TFA
CAS: F: C93H150N20O25.xC2HF3O2 W: 1948.31 (free acid)
mSIRK TFA (G-Protein βγ Binding Peptide) is an cell-permeable activator of ERK1/2, with EC50 of 2.5-5 μM. mSIRK TFA d
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