| Bioactivity | mPGES-1/5-LOX-IN-1 (compound 3j) is a potent and orally active mPGES-1 and 5-LOX dual inhibitor with IC50 values of 0.92, 1.89 µM, respectively. mPGES-1/5-LOX-IN-1 shows anti-inflammatory impact[1]. |
| In Vivo | mPGES-1/5-LOX-IN-1 (compound 3j) (10 mg/kg; p.o.) 具有抗炎作用，可降低促炎细胞因子 (PGE2、TNF-α 和 IL-6) 的水平，且具有胃肠道安全性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C20H22N4O6S |
| Molar Mass | 446.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Al-Wahaibi LH, et al. Design and synthesis of new dihydropyrimidine/sulphonamide hybrids as promising anti-inflammatory agents via dual mPGES-1/5-LOX inhibition. Front Chem. 2024 May 10;12:1387923. |