mG2N001_product_DataBase

Bioactivity	mG2N001 is a negative allosteric modulator (NAM) (IC50: 93 nM) of the metabotropic glutamate receptor mGluR2 and binds to mGluR2 as an antagonist (Ki: 63 nM). mG2N001 is microparticle- and plasma-stable, and its radioisotope [11C]mG2N001 can be used in PET imaging. [11C]mG2N001 has good brain heterogeneity and brain penetration, and can selectively accumulate in mGluR2-rich regions, producing high-contrast brain images[1].
In Vivo	mG2N001 (63.0-87.3 MBq [11C]mG2N001, iv.) 可在大鼠和食蟹猴体内实行 PET 成像实验，表现出 mGluR2 的特异性结合活性，清楚显示动物脑中 mGluR2 的生物分布图[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2760515-88-4
Formula	C18H19FN2O3
Molar Mass	330.35
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yuan G, et al. Synthesis and Characterization of 5-(2-Fluoro-4-[11C]methoxyphenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridine-7-carboxamide as a PET Imaging Ligand for Metabotropic Glutamate Receptor 2. J Med Chem. 2022 Feb 10;65(3):2593-2609.

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