| Bioactivity | m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-Amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
| Invitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins |
| Name | m-PEG11-Amine |
| CAS | 854601-60-8 |
| Formula | C23H49NO11 |
| Molar Mass | 515.64 |
| Appearance | Solid-liquid mixture |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Erwin R. Boghaert, et al. Anti-egfr antibody drug conjugates. WO2017214282A1. |
m-PEG11-Amine
CAS: 854601-60-8 F: C23H49NO11 W: 515.64
m-PEG11-Amino is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG11-Amine is also
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