m-PEG10-acid_product_DataBase

Bioactivity	m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
Invitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
Name	m-PEG10-acid
CAS	2409969-94-2
Formula	C22H44O12
Molar Mass	500.58
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. John F. Donovan et al. Pegylated prodrugs of phenolic trpv1 agonists. WO2020023794A1. [2]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

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