| Bioactivity | l-Pindolol ((-)-pindolol) is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease[1][2][3]. | ||||||||||||
| Invitro | l-Pindolol (500 nM 和 1 μM) 拮抗 5-羧胺色胺 (5-CT；10 nM) 和 5-羟色胺 (5-HT；15 μM) 通过检测 5-CT 和 5-HT 对 CA1 锥体细胞的膜超极化[1]。l-Pindolol (1 nM-100 μM) 抑制 100 nM 5-CT 诱导的 CA1 锥体细胞超极化，IC50 值为 92 nM[1]。l-Pindolol (1 nM-100 μM) 抑制 300 nM 5-CT 引起的 CA3 神经元超极化，IC50 值为 522 nM[1]。 | ||||||||||||
| In Vivo | l-Pindolol (15 mg/kg；腹腔注射，[3H]-WAY 100635 注射前预处理) 减少了 [3H]-WAY 100635 在含有 5-HT1A 受体的脑区的积累。 Animal Model: | ||||||||||||
| Name | l-Pindolol | ||||||||||||
| CAS | 26328-11-0 | ||||||||||||
| Formula | C14H20N2O2 | ||||||||||||
| Molar Mass | 248.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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