| Bioactivity | iso-ADP ribose (isoADPr) is a fluorescence polarization probe used for protein nucleic acid modification. iso-ADP ribose is a structure comprising parts of two consecutive ADP-ribosyl units within the PAR chain. iso-ADP ribose is the small-molecule ligand for RING finger protein 146 (RNF146) WWE. A single iso-ADP ribose molecule triggers the activation of RNF146 by interacting with the basic Lys61 residue in the RING domain[1][2]. |
| CAS | 15720-01-1 |
| Formula | C15H23N5O14P2 |
| Molar Mass | 559.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kewen Peng, et al. Iso-ADP-Ribose Fluorescence Polarization Probe for the Screening of RNF146 WWE Domain Inhibitors. ACS Chem Biol. 2024 Feb 16;19(2):300-307. [2]. Federico Teloni, et al. Readers of poly(ADP-ribose): designed to be fit for purpose. Nucleic Acids Res. 2016 Feb 18;44(3):993-1006. |
iso-ADP ribose
CAS: 15720-01-1 F: C15H23N5O14P2 W: 559.32
iso-ADP ribose (isoADPr) is a fluorescence polarization probe used for protein nucleic acid modification. iso-ADP ribose
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