| Bioactivity | iNOs-IN-1 (YPW) is a potent inducible nitric oxide synthase (iNOS) inhibitor. iNOs-IN-1 can significantly inhibit the expression of IL-6 and iNOS, as well as reduce LPS-induced NO generation with dose-dependent manner in mouse macrophages. Anti-inflammatory effects[1]. |
| Invitro | iNOs-IN-1 (YPW) (12.5, 25 and 50 µM; 2 hours) can significantly reduce NO production in LPS-treated RAW 264.7 cells[1].iNOs-IN-1 (12.5, 25 and 50 µM; 2 hours) inhibits IL-6 production and iNOS protein expression in LPS-treated RAW 264.7 mouse macrophages[1]. Western Blot Analysis Cell Line: |
| Name | iNOs-IN-1 |
| Formula | C25H30N4O5 |
| Molar Mass | 466.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Peng Y, et al. Identification and molecular mechanism of a tri-peptide inhibitor targeting iNOS from duck embryo protein hydrolysates by experimental and bioinformatics studies. Bioorg Chem. 2022;122:105736. |