| Bioactivity | iNOS/TopoI-IN-1 (compound AuL9) is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant activities. iNOS/TopoI-IN-1 inhibits the growth of breast cancer cells MCF-7 and MDA MB-231 in vitro with IC50 of 3.5 μM and 6.3 μM, respectively, and induces DNA damage and apoptosis of breast cancer cells by inhibiting human topoisomerase I (TopoI) (Ki=2.72 μM). In addition, NOS/TopoI-IN-1 inhibits the expression of iNOS by inhibiting the activation of NF-kB (Ki=1.49 μM)[1]. |
| Formula | C34H40AuBrCl2N3OS |
| Molar Mass | 886.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. D'Amato, et al. "Design, synthesis and biological evaluation of multitarget hybrid molecules containing NHC-Au (I) complexes and carbazole moieties." European Journal of Medicinal Chemistry (2024): 116757. |
iNOS/TopoI-IN-1
CAS: F: C34H40AuBrCl2N3OS W: 886.54
iNOS/TopoI-IN-1 (compound AuL9) is a multi-target hybrid molecule with anti-tumor, anti-inflammatory and antioxidant act
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