| Bioactivity | iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 and IL-6 signaling pathways. iJak-381 also reduced p-STAT6 levels and inhibited the influx of inflammatory cells into the lungs of mice. iJak-381 inhibits airway hyperresponsiveness (AHR)[1]. |
| Target | STAT6; JAK1; JAK2 |
| CAS | 1831144-46-7 |
| Formula | C28H28ClF2N9O3 |
| Molar Mass | 612.03 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zak M, et al. Inhaled Janus Kinase (JAK) inhibitors for the treatment of asthma. Bioorg Med Chem Lett. 2019 Oct 15;29(20):126658. |
iJak-381
CAS: 1831144-46-7 F: C28H28ClF2N9O3 W: 612.03
iJak-381 is a JAK1/2 inhibitor with anti-inflammatory activity. iJak-381 blocks IL-13 signaling and also inhibits IL-4 a
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