| Bioactivity | hGAPDH-IN-1, a 3-bromo-4,5-dihydroisoxazole derivative, is a specific and potent hGAPDH covalent inhibitor. hGAPDH-IN-1 reduces cancer cell growth in different pancreatic cancer cell lines. |
| Invitro | hGAPDH-IN-1 (化合物 11; 1-100 μM; 48 小时) 可显着降低腺癌细胞系中的癌细胞生长[1]。 Cell Viability Assay[1] Cell Line: |
| Name | hGAPDH-IN-1 |
| Formula | C12H12BrNO |
| Molar Mass | 266.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Andrea Galbiati, et al. Discovery of a spirocyclic 3-bromo-4,5-dihydroisoxazole covalent inhibitor of hGAPDH with antiproliferative activity against pancreatic cancer cells. Eur J Med Chem. 2023 Apr 6;254:115286. |