Bioactivity | hDHODH-IN-2 is an analogue of the active metabolite of Leflunomide. hDHODH-IN-2 is a human dihydroorotate dehydrogenase (hDHODH) inhibitor. hDHODH-IN-1 has anti-inflammatory activity[1][2]. |
Invitro | hDHODH-IN-2 (Compound 42) inhibits rat and mouse DHODH with log(1/IC50) values of 5.83 and 5.80, respectively in self-organizing molecular field analysis (SOMFA)[1]. |
Name | hDHODH-IN-2 |
CAS | 183946-00-1 |
Formula | C19H16N2O2 |
Molar Mass | 304.34 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active metabolite of leflunomide. Int J Mol Sci. 2011;12(5):2982-93. [2]. Shih KC, et al. Development of a human dihydroorotate dehydrogenase (hDHODH) pharma-similarity index approach with scaffold-hopping strategy for the design of novel potential inhibitors. PLoS One. 2014 Feb 4;9(2):e87960. |