| Bioactivity | hDHODH-IN-12 is a potent DHODH inhibitor with an IC50 value of 0.421 μM. DHODH is the rate-limiting enzyme in the de novo synthesis of pyrimidine which is essential in DNA/RNA Synthesis. hDHODH-IN-12 is present in the inner membrane of human mitochondria.hDHODH-IN-12 can be used for the research of lung cancer[1]. |
| Target | IC50: 0.421 μM (DHODH) |
| Invitro | hDHODH-IN-12 (compound 5c) (100 μM; 24 h) 对 A549， H1299 和 H1975 细胞系的 TC50 值为 11μM, 11μM, 15μM[1]。hDHODH-IN-12 (compound 5c) (100 μM; 24 h) 在 A549， H1299 和 H1975 细胞系中降低细胞活力[1]。 Cell Viability Assay[1] Cell Line: |
| Name | hDHODH-IN-12 |
| Formula | C22H15F3N4O3 |
| Molar Mass | 440.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nada H, et al. Identification of Potent hDHODH Inhibitors for Lung Cancer via Virtual Screening of a Rationally Designed Small Combinatorial Library. ACS Omega. 2023 Jun 8;8(24):21769-21780. |