| Bioactivity | hCYP1B1-IN-2 (compound 3n) is a potent human cytochrome P450 1B1 enzyme hCYP1B1 inhibitor. hCYP1B1-IN-2 shows the extremely potent anti-hCYP1B1 activity (IC50=0.040 nM) and blocks AhR transcription activity. hCYP1B1-IN-2 potently inhibits hCYP1B1 via a mix inhibition manner, showing a Ki value of 21.71 pM[1]. |
| Invitro | hCYP1B1-IN-2 (compound 3n) (5 μM) 可以显著逆转 H460/PTX 细胞中的紫杉醇（PTX、HY-B0015）耐药性，其证据是 IC50 值从 632.6 nM（单独使用 PTX）降至 100.8 nM（PTX 加 3n）[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> hCYP1B1-IN-2 相关抗体: |
| Formula | C17H10BrN3O2 |
| Molar Mass | 368.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wei Y, et al. Design, synthesis and structure-activity relationship of 1,8-naphthalimide derivatives as highly potent hCYP1B1 inhibitors. Bioorg Med Chem Lett. 2024 Jul 15;107:129776. |