| Bioactivity | hCAIX/XII-IN-1 is a potent CAIX/XII inhibitor with the KI values of 0.48 µM and 0.83 µM for CAIX and CAXII, respectively. hCAIX/XII-IN-1 shows antiproliferative activity in vitro. hCAIX/XII-IN-1 induces apoptosis in MCF-7 cells[1]. |
| Target | KI: 0.48 µM (CAIX); 0.83 µM (CAXII) |
| Invitro | hCAIX/XII-IN-1 (compound 11a) (3.125, 6.25, 12.5, 25, 50 µM, 48 h) shows antiproliferative activity with an IC50 value of 0.48 µM in MCF-7 cells[1].hCAIX/XII-IN-1 (0.48 µM; 24 h) increases the cell populations of Sub-G1 phase[1].hCAIX/XII-IN-1 (0.48 µM) induces apoptosis in MCF-7 cells[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | hCAIX/XII-IN-1 |
| Formula | C19H11NO5S2 |
| Molar Mass | 397.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Eldehna WM, et al. Discovery of 2,4-thiazolidinedione-tethered coumarins as novel selective inhibitors for carbonic anhydrase IX and XII isoforms. J Enzyme Inhib Med Chem. 2022; 37(1):531-541. |