| Bioactivity | hCAI/II-IN-8 (Compound 8) is a hydrazide derivative based on 4-hydroxybenzaldehyde. hCAI/II-IN-8 primarily targets human carbonic anhydrase isomerase I (hCA I) and II (hCA II) for inhibition (IC50 = 21.35 ± 0.39 nM (hCA I); 7.12 ± 0.12 nM (hCA II)). hCAI/II-IN-8 inhibits AChE and BChE as well(IC50 = 46.27 ±0.75 nM (AChE); 43.38 ± 0.83 nM (BChE)). [1].[1]. |
| Invitro | hCAI/II-IN-8 通过与 hCA I 和 hCA II 中的关键残基形成了多个氢键和疏水相互作用，来进行高效的活性抑制。且与酶的结合有较高的稳定性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> hCAI/II-IN-8 相关抗体: |
| Formula | C22H20N4O3 |
| Molar Mass | 388.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Çakmak, R.et al. Synthesis of Novel Hydrazide–Hydrazone Compounds and In Vitro and In Silico Investigation of Their Biological Activities against AChE, BChE, and hCA I and II. ACS Omega, 9(18), 20030–20041. |