| Bioactivity | hCA/VEGFR-2 IN-5 (compound 9) is an indolone-phenylsulfonamide and a potential dual inhibitor of cancer-related hCA IX/XII and VEGFR-2. The IC50 values of hCA/VEGFR-2-IN-5 for VEGFR-2, hCA IX and hCA XII are 0.38 μM, 40 and 3.2 nM, respectively. hCA/VEGFR-2-IN-5 has antitumor activity[1]. |
| Invitro | hCA/VEGFR-2-IN-5 对 HepG-2 和 MCF-7 细胞的 IC50 为 8.39~16.90 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> hCA/VEGFR-2-IN-5 相关抗体: |
| Formula | C26H34N4O10S |
| Molar Mass | 594.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Abbas HS, et al. New sulfonamide-based glycosides incorporated 1,2,3-triazole as cytotoxic agents through VEGFR-2 and carbonic anhydrase inhibitory activity. Sci Rep. 2024 Jun 6;14(1):13028. |