| Bioactivity | hAChE/hBACE-1-IN-3 (Compound 23a) is a mixed-type inhibitor of hAChE and hBACE-1 with IC50 values of 0.32 μM and 0.39 μM, respectively, Ki values of 0.26 μM and 0.46 μM, respectively. hAChE/hBACE-1-IN-3 can penetrate the blood-brain barrier[1]. |
| Target | IC50: 0.32 μM (hAChE), 0.39 μM (hBACE-1) |
| Name | hAChE/hBACE-1-IN-3 |
| Formula | C25H31N3O3 |
| Molar Mass | 421.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Banoo R, et al. Design, synthesis, and pharmacological evaluation of indole-piperidine amides as Blood-brain barrier permeable dual cholinesterase and β-secretase inhibitors. Eur J Med Chem. 2024 Jan 6;266:116131. |