| Bioactivity | hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 could be used for obesity research[1]. |
| Invitro | ACC2 isoform, presents on the mitochondrial surface, inhibits carnitine palmitoyl transferase 1 (CPT-1) and converts acetyl-CoA into malonylCoA for de novo lipogenesis in the cytosol[1].ACCs inhibition will change cellular substrate and favour lipid oxidation, thus preventing deleterious lipids from accumulating in oxidative tissue such as muscle, heart and liver[1].hACC2-IN-1 shows good potency against the human ACC2 (hACC2) enzyme[1]. |
| Name | hACC2-IN-1 |
| CAS | 192323-14-1 |
| Formula | C23H32N2O4S |
| Molar Mass | 432.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bengtsson C, et al. Design of small molecule inhibitors of acetyl-CoA carboxylase 1 and 2 showing reduction of hepatic malonyl-CoA levels in vivo in obese Zucker rats. Bioorg Med Chem. 2011 May 15;19(10):3039-53. |
hACC2-IN-1
CAS: 192323-14-1 F: C23H32N2O4S W: 432.58
hACC2-IN-1 is a potent acetyl-CoA carboxylase 2 (ACC2) inhibitor, with an IC50 value of 2.5 μM (hACC2). hACC2-IN-1 coul
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