| Bioactivity | eIF4A3-IN-17 (compound 61) is a silvestrol (HY-13251) analogue. eIF4A3-IN-17 interferes the assembling of eIF4F translation complex with EC50s of 0.9, 15 and 1.8 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-17 can be used for the research of human cancer pathogenesis[1]. |
| Name | eIF4A3-IN-17 |
| CAS | 1402931-75-2 |
| Formula | C28H25NO7 |
| Molar Mass | 487.50 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Liu T, et al. Synthetic silvestrol analogues as potent and selective protein synthesis inhibitors. J Med Chem. 2012 Oct 25;55(20):8859-78. |
eIF4A3-IN-17
CAS: 1402931-75-2 F: C28H25NO7 W: 487.50
eIF4A3-IN-17 (compound 61) is a silvestrol(HY-13251) analogue. eIF4A3-IN-17 interferes the assembling of eIF4F translati
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