| Bioactivity | diABZI-V/C-DBCO (Compound 3) is a potent STING agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cathepsin B to activate STING, leading to the production of interferons and other immune-stimulatory molecules, thereby enhancing the immune system's response to tumors. The EC50 values for diABZI-V/C-DBCO and diABZI-amine in activating STING in THP1-Dual cells are 1.47 and 0.144 nM, respectively, and in primary mouse splenocytes, the EC50 values are 7.7 and 0.17 μM, respectively. diABZI-V/C-DBCO can be used in cancer immunotherapy research[1]. |
| CAS | 3035557-60-6 |
| Formula | C78H89N19O13 |
| Molar Mass | 1500.66 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Sheehy TL, et al. STING-Activating Polymer-Drug Conjugates for Cancer Immunotherapy. bioRxiv [Preprint]. 2024 Apr 12:2024.03.23.585817. |
diABZI-V/C-DBCO
CAS: 3035557-60-6 F: C78H89N19O13 W: 1500.66
diABZI-V/C-DBCO (Compound 3) is a potent STING agonist. diABZI-V/C-DBCO can release diABZI-amine upon activation by cath
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