| Bioactivity | ddhCTP is a nucleoside analog and inhibits the synthesis of DNA by specifically inhibiting the activity of DNA polymerase with the Ki values of 1.32 and 0.034 μM for DNA polymerase beta and DNA polymerase gamma[1][2]. |
| CAS | 2279171-34-3 |
| Formula | C9H14N3O13P3 |
| Molar Mass | 465.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ciardullo G, et al. Viral RNA Replication Suppression of SARS-CoV-2: Atomistic Insights into Inhibition Mechanisms of RdRp Machinery by ddhCTP. J Chem Inf Model. 2024;64(5):1593-1604. [2]. Cherrington JM, et al. Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, ddCTP, AZTTP, and FIAUTP with human DNA polymerases beta and gamma. Biochem Pharmacol. 1994;48(10):1986-1988. |
ddhCTP
CAS: 2279171-34-3 F: C9H14N3O13P3 W: 465.14
ddhCTP is a nucleoside analog and inhibits the synthesis of DNA by specifically inhibiting the activity of DNA polymeras
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