| Bioactivity | dCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells[1]. | ||||||||||||
| Invitro | dCeMM1 (0-100 µM; 3 days) 抑制细胞生长，WT 和 UBE2Mmut KBM7 细胞的 EC50 分别为 3、8 µM[1 ].dCeMM1 (10 µM; 12, 16 h) 降低 WT KBM7 细胞中 RBM39 的表达水平[1]。 Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | dCeMM1 | ||||||||||||
| CAS | 118719-16-7 | ||||||||||||
| Formula | C14H13BrN2O3S | ||||||||||||
| Molar Mass | 369.23 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Mayor-Ruiz C, et al. Rational discovery of molecular glue degraders via scalable chemical profiling. Nat Chem Biol. 2020 Nov;16(11):1199-1207. |
dCeMM1
CAS: 118719-16-7 F: C14H13BrN2O3S W: 369.23
dCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4DCAF15 ligase. dCeMM1 de
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.