| Bioactivity | d-GLP-2 E33A is an agonist for the glucagon-like peptide 2 receptor (GLP-2R) with an EC50 of 414 nM. d-GLP-2 E33A can activate GLP-2R and increase the phosphorylation of AKT, but has no stimulative effect on GLP-1R. d-GLP-2 E33A can be used in the study of diseases such as intestinal malabsorption and inflammatory bowel diseases[1]. |
| Target | EC50: 414 nM (GLP-2R) |
| Sequence | Ac-Ile-Lys-Ala-Gln-Trp-Leu-Ala-Ala-Glu-Phe-Ile-Gln-Ala-Val-Ala-Ala-Val-Leu-Ala-Met-Leu-Arg-Asn-Asn-Gln-Phe-Glu-Phe-Ala-Gly-Val-Ala-His-NH-NH2 |
| Shortening | Ac-IKAQWLAAEFIQAVAAVLAMLRNNQFEFAGVAH-NH-NH2 |
| Formula | C170H263N47O43S |
| Molar Mass | 3685.26 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Valiente PA, et al. Computational Design of Potent and Selective d-Peptide Agonists of the Glucagon-like Peptide-2 Receptor. J Med Chem. 2023 Aug 10;66(15):10342-10353. |