| Bioactivity | cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers[1]. |
| CAS | 1446322-73-1 |
| Sequence | cyclo(Cys-Leu-Leu-Phe-Val-Tyr) |
| Shortening | cyclo(CLLFVY) |
| Formula | C38H54N6O7S |
| Molar Mass | 738.94 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Miranda E, et al., A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells. J Am Chem Soc. 2013 Jul 17;135(28):10418-25. |
cyclo(CLLFVY)
CAS: 1446322-73-1 F: C38H54N6O7S W: 738.94
cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.