| Bioactivity | Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts as an irreversible 20S proteasome inhibitor. |
| Target | 20S proteasome |
| Invitro | Clasto-Lactacystin β-lactone is a natural active metabolite of lactacystin, which is a metabolite of Streptomyces. Clasto-Lactacystin β-lactone is the cell cycle progression in an osteosarcoma cell line[1]. Clasto-Lactacystin β-lactone is an irreversible 20S proteasome inhibitor, and also acts as a partial inhibitor of branched amino acid preferring peptidase (BrAAP). β-Lactone inactivates approximately 60% of the BrAAP activity rapidly, and the remaining 40% of the BrAAP activity is inactivated by β-lactone at a 50-fold slower rate[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> clasto-Lactacystin β-lactone 相关抗体: |
| CAS | 154226-60-5 |
| Formula | C10H15NO4 |
| Molar Mass | 213.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fenteany G, et al. A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3358-62. [2]. McCormack TA, et al. Kinetic studies of the branched chain amino acid preferring peptidase activity of the 20S proteasome: development of a continuous assay and inhibition by tripeptide aldehydes and clasto-lactacystin beta-lactone. Biochemistry. 1998 May 26;37(21):7792-800. |
clasto-Lactacystin β-lactone
CAS: 154226-60-5 F: C10H15NO4 W: 213.23
Clasto-Lactacystin β-lactone, a natural active metabolite of lactacystin, which is a metabolite of Streptomyces, acts a
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