| Bioactivity | cis VH-298 is a cis-form of VH-298 (HY-100947). VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a Kd value of 80 to 90 nM, used in PROTAC technology[1]. |
| Name | cis VH-298 |
| CAS | 2097381-86-5 |
| Formula | C27H33N5O4S |
| Molar Mass | 523.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Frost J, et al. Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition. Nat Commun. 2016 Nov 4;7:13312. |
cis VH-298
CAS: 2097381-86-5 F: C27H33N5O4S W: 523.65
cis VH-298 is a cis-form of VH-298 (HY-100947). VH-298 is a highly potent inhibitor of the VHL:HIF-α interaction with a
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