cis-Epoxysuccinic acid_product_DataBase

Bioactivity	cis-Epoxysuccinic acid is a succinate receptor (SUCNR1/GPR91) agonist. cis-Epoxysuccinic acid inhibits cAMP levels with an EC50 value of 2.7 µM. cis-Epoxysuccinic acid can be used for the research of cardiovascular system[1].
Invitro	cis-Epoxysuccinic acid (1-100 μM; 10 min) affects cAMP levels of HEK293 cells[1].cis-Epoxysuccinic acid (0.1 μM-100 mM; 1 h) agonists SUCNR1 pathways without affects succinate dehydrogenase[1]. Cell Viability Assay[1] Cell Line:
In Vivo	cis-Epoxysuccinic acid (1 mg/kg; i.v. once) has an effect on the blood pressure of rats[1]. Animal Model:
Name	cis-Epoxysuccinic acid
CAS	16533-72-5
Formula	C4H4O5
Molar Mass	132.07
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Geubelle P, et al. Identification and pharmacological characterization of succinate receptor agonists. Br J Pharmacol. 2017 May;174(9):796-808.

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