| Bioactivity | cMCoFx1 is a potent and selective FXIIa cyclic peptide inhibitor. cMCoFx1 has high binding affinity (KD: 900 pM) and inhibitory activity (Ki: 370 pM) for FXIIa. cMCoFx1 can effectively inhibit endogenous clotting pathways, and cMCoFx1 is stable in serum and non-cytotoxic[1]. |
| Target | Ki: 370 pM (FXIIa) |
| CAS | 2853605-24-8 |
| Sequence | cyclo(Asp-Gly-Gly-Ile-Cys-Pro-Arg-Ile-Gly-Arg-Leu-Cys-Arg-Arg-Asp-Ser-Asp-Cys-Pro-Gly-Ala-Cys-Ile-Cys-Arg-Ala-Thr-Arg-Phe-Cys-Gly-Ser-Gly-Tyr) (disulfide bridge: Cys2-Cys19; Cys4-Cys26; Cys10-Cys32) |
| Shortening | cyclo(ACICRATRFCGSGYDGGICPRIGRLCRRDSDCPG) (disulfide bridge: Cys2-Cys19; Cys4-Cys26; Cys10-Cys32) |
| Formula | C146H232N52O44S6 |
| Molar Mass | 3612.12 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu W, et al. An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold. J Am Chem Soc. 2021 Nov 10;143(44):18481-18489. |
cMCoFx1
CAS: 2853605-24-8 F: C146H232N52O44S6 W: 3612.12
cMCoFx1 is a potent and selective FXIIa cyclic peptide inhibitor. cMCoFx1 has high binding affinity (KD: 900 pM) and inh
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