| Bioactivity | cGAS-IN-3 (compound 30d-S) is an orally active cyclic GMP-AMP synthase (Cyclic GMP-AMP Synthase/cGAS) inhibitor with good plasma exposure and low clearance. cGAS-IN-3 has anti-inflammatory activity and can significantly reduce lung inflammation in rats[1].br/[16][1]. |
| Target | cGAS |
| Invitro | cGAS-IN-3 在小鼠 RAW-Lucia 细胞中对 cGAS 的抑制效力 (IC50) 为 2.87 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> cGAS-IN-3 相关抗体: |
| In Vivo | cGAS-IN-3 (30 mg/kg; po; 单剂量) 对 LPS 诱导的急性肺损伤 (ALI) 小鼠模型具有预防作用，可有效减轻炎症[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C21H20Cl2F2N4O2 |
| Molar Mass | 469.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen M, et al. Design, Synthesis, and Pharmacological Evaluation of Spiro[carbazole-3,3'-pyrrolidine] Derivatives as cGAS Inhibitors for Treatment of Acute Lung Injury. J Med Chem. 2024 Apr 25;67(8):6268-6291. |