| Bioactivity | cGAS-IN-1 (compound C20) is a flavonoid and Cyclic GMP-AMP Synthase (cGAS) inhibitor with IC50s of 2.28 μM (human cGAS) and 1.44 μM (mouse cGAS). Abnormal activation of cGAS is associated with a variety of immune-mediated inflammatory diseases, and cGAS-IN-1 has potential anti-inflammatory activity[1]. |
| Target | IC50: 2.28 μM (human cGAS); 1.44 μM (mouse cGAS) |
| Name | cGAS-IN-1 |
| CAS | 858770-07-7 |
| Formula | C18H19NO8 |
| Molar Mass | 377.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li J, et al. Discovery of novel cGAS inhibitors based on natural flavonoids. Bioorg Chem. 2023 Nov;140:106802.. . |