| Bioactivity | cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP diammonium activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators[1][2][3][4]. |
| Invitro | cGAMP disodium promotes the antigen-specific proliferation capacity of spleen cells in mice[2].cGAMP disodium directly activates murine and human dendritic cells in vitro[2].On stimulation with cGAMP disodium, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)[3].cGAMP disodium activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs[4]. |
| Name | cGAMP disodium |
| CAS | 2407516-83-8 |
| Formula | C20H22N10Na2O13P2 |
| Molar Mass | 718.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
cGAMP disodium
CAS: 2407516-83-8 F: C20H22N10Na2O13P2 W: 718.37
cGAMP (Cyclic GMP-AMPP) disodium functions as an endogenous second messenger in metazoans and triggers interferon produc
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