c-Myc inhibitor 7_product_DataBase

Bioactivity	c-Myc inhibitor 7 is a c-Myc inhibitor and a multiple target protein degrader. c-Myc inhibitor 7 effective degrades c-MYC, CK1α, GSPT1 and IKZF1/2/3 proteins in a variety of tumor cells. c-Myc inhibitor 7 can be used for c-Myc high expression related disease research, such as cancer, cardiovascular and cerebrovascular diseases, and viral infection[1].
Invitro	c-Myc inhibitor 7 (0-10 mM；3 天) 抑制 HL60 细胞增殖，IC50 值为 0.5 nM[1]。c-Myc inhibitor 7 促进 60-90% HL60 细胞中蛋白的降解[1]。c-Myc inhibitor 7 (1，3，10 和 100 nM；24 小时) 在多种细胞系中降解 c-Myc，CKla，GSPTl，IKZFl，IKZF2 和 IKZF3 蛋白[1]。
Name	c-Myc inhibitor 7
CAS	2883535-99-5
Formula	C35H30N6O5
Molar Mass	614.65
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. TONG YOUZHI, et al. 2,6-Dioxopiperidine compounds as c-Myc inhibitors and their preparation, pharmaceutical compositions and use in the treatment of diseases. WO2022268066. 2022.

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