| Bioactivity | c-Met/HDAC-IN-4 is a dual inhibitor of c-Met/HDAC. The IC50 value of c-Met/HDAC-IN-4 for c-Met is 28.92 nM. c-Met/HDAC-IN-4 can induce G0/G1 phase cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells, and it inhibits the proliferation and invasion of breast cancer cell lines[1]. |
| Formula | C37H36N8O |
| Molar Mass | 608.73 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang Z, et al. Design and Synthesis of c-Met and HDAC Dual Inhibitors for the Treatment of Breast Cancer[J]. ACS Medicinal Chemistry Letters, 2024. |