| Bioactivity | c-Met-IN-18 is ATP competitive type-III c-MET inhibitor of WT and D1228V mutant c-MET. c-Met-IN-18 has inhibitory for WT/D1228V with an IC50 value of 0.013/0.20e.c-Met-IN-18 can be used for the research of c-MET driven cancers[1]. |
| Target | IC50: 0.013/0.20e (WT/D1228V). |
| Name | c-Met-IN-18 |
| Formula | C21H15FN4O2 |
| Molar Mass | 374.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Michaelides IN, et al. Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J Med Chem. 2023 Jul 13;66(13):8782-8807. |