| Bioactivity | c-Met-IN-17 is a potent c-Met kinase inhibitor with an IC50 of 0.031 μM. c-Met-IN-17 can be used in anticancer research.[1]. |
| Invitro | c-Met-IN-17 (compound 29) 通过 ADP-Glo 实验，测定了抑制D1228V c-MET 酶活性的 IC50 值为0.068 μM[1]。 |
| In Vivo | c-Met-IN-17 (0.5 mg/kg; 静脉注射; 0-24 小时) 在 Wistar 大鼠体内显示出优异的生物利用度[1]。Wistar 大鼠体内药代动力学分析[1]Route |
| Name | c-Met-IN-17 |
| Formula | C21H15FN4O2 |
| Molar Mass | 374.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Michaelides IN, et al. Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor. J Med Chem. 2023 Jul 13;66(13):8782-8807. |